Chagas disease, also known as American trypanosomiasis, is a parasitic disease caused by the protozoan parasite Trypanosoma cruzi. The disease is primarily transmitted to humans and other mammals through the bite of triatomine bugs, also known as kissing bugs. Chagas disease is endemic to Latin America but has been increasingly recognized in other regions of the world due to global migration. The acute phase of Chagas disease may present with fever, swelling at the site of the insect bite, and enlargement of the liver and spleen. If left untreated, the chronic phase of the disease can lead to severe complications such as heart disease, digestive issues, and neurological problems. Chagas disease is a major public health concern in many endemic countries, affecting millions of people and causing significant morbidity and mortality. Current research in the field of Chagas disease focuses on various aspects of the disease, including improving diagnosis and treatment methods, developing vaccines, studying the transmission dynamics of the parasite, and understanding the pathogenesis of the disease. Efforts are also being made to raise awareness about Chagas disease and implement control measures to reduce the burden of this neglected tropical disease.